2- Predictions program SIMPA (J. Levin & J. Garnier, Biochim. Biophys. Acta, 1988, 28, 1177-92) with multiple alignments of homologous sequences (J. Levin et al. Protein Eng., 1993, 6, 849-54). When no homologous structure is known but homologous sequences are known, the cross validated Q3 can be improved from 63-65% to 69-70% by averaging the predictions at each position of a multiple alignment of the known homologous sequences (program CONSENSUS).
3- Program COMBINE (V. Biou et al. Prot. Eng. 1988, 2, 185-191) with
multiple alignments of homologous sequences. COMBINE is an expert
program of three secondary structure prediction algorithms: GOR III,
SIMPA and Bit Pattern. This latter prediction program is based on
hydrophobicity patterns and has a cross validated Q3 of 59%. COMBINE
cross-validated Q3 is about 65%. COMBINE can be associated to CONSENSUS
to yield an accuracy of 69-70% (V. Di Francesco, P.J. Munson and
Garnier J., 28th Hawaii International Conference on System Science,
1995.
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